Thursday, December 27, 2012

What are the cause's of the vitamin B12 deficiency?

Q. What are the causes of the vitamin B12 deficiency? Is the lake od sleep a cause of vitamin B (and B12) deficiency? Can someone give me some professional answer's?!

A. B12 is absorbed in the stomach. It requires a transport factor to get into the blood stream. This factor, called Intrinsic Factor , is manufacured by cells called Parietal cells in the stomach. In Pernicious Anemia, there are antibodies to the Parietal cells that shuts them down. No intrinsic factor, B12 not absorbed. Other causes are a strict vegetarian diet, Loss of that part of the stomach surgically, cancer of the stomach, chronic gastritis.

Cyanocobalamin is inert. It is the form the vitamin is excreted in, after binding with CN- ions. The active vitamin is hydroxocobalamin. The easiest way to replace B12 is to take Methylcobalamin sublingual. The sublingual route bypasses the gut, and Methylcobalamine is demethylated to hydroxocobolamin.

Lack of sleep does not cause a deficiency. a really bad diet can. Lack of sleep can cause other problems, tho, and you might consider talking with someone about your difficulty. If you are not a Medical Student or Resident, in the Military or in some other job that demands long hours, see someone.


anyone know symptoms of vitamin b12 deficiency?
Q. i've been really tired lately and losing weight, i weigh around 99lbs. i used to weigh 125lbs. i get really shakey and need to carry food with me. i get out of breath.and my hair is getting so dry and thin. i've said something to my doctor about the weight and he said you look fine, but i don't think it's normal to lose weight for no reason and i just don't feel well and i look awful too. i know taking medicine for reflux can cause vitamin b12 deficiency and i take nexium for years.

A. Sudden unexplained weight loss should always be investigated to find out the cause, especially if you also feel tired and shaky. Your doctor will want to check you for diabetes, overactive thyroid gland, hidden infections, and other causes of weight loss. He or she will probably arrange blood tests and a chest x-ray. Don't put off going - the sooner the cause is found, the sooner you can be treated and on the way to recovery.

Sometimes weight loss can be a sign of a depressive illness, and your doctor will want to know how you are feeling emotionally. In the meantime, try to eat a healthy diet. It can help to keep a food diary for a few days to see exactly what you are eating. Healthy between-meal-snacks such as fruit, muesli, smoked salmon sandwiches, and cheese can help you put on weight. High-carb foods such as rice, pasta and bread are also a good idea. good luck


Problem concerning vitamin b12 deficiency?
Q. I have vitamin b12 deficiency and I heard that it leads to irreversable brain damage. Even after taking the supplement there is no cure. I have memory and other neurological problems. So there is no cure for it?

A. That seems hard to believe. I have not heard it. I have been taking the B12 pills for decades, not problem.


What is the difference between methylmalonic acid and methionine?
Q. The question is about Vitamin B12 deficiency

A. Methionine is an essential amino acids present in humans. Methylmalonic acid is a is a dicarboxylic acid.

The coenzyme A linked form of methylmalonic acid, methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle, and is thus part of one of the anaplerotic reactions.





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